The Slayer special property will increase the damage dealt to a specific creature type.

Creature Type Quest/Item
Ghost Spectral Weapons
Tumerok Assault Weapons
Jester (Touched) Ball of Fire
Virindi Singularity Weapons
Tusker Tusker Paw Wand
Shadow
Undead Search for Lunnum
Replica BloodScorch
Viamontian Knight Replica Sword of Bellenesse

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