The Slayer special property will increase the damage dealt to a specific creature type. In general this is more useful to mages, especially when it is a quest weapon with stats inferior to tinkered loot weapons. (By using the quest weapon, a melee/archer is usually giving up the chance to use armor rend or critical strike and so gains little, whereas the mage gets essentially a double vuln). If you are looking for all items that have a particular slayer property, see here.
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