How do I play AC under Linux?
http://forums.ac.turbine.com/showthread.php?t=35677
The appdb for wine's listing for the ac trial but the information applies to the full game as well. There's some good tips if your having some problems getting it running, it helped me get it going.
http://appdb.winehq.org/objectManager.php?sClass=version&iId=7243